Descovy® (emtricitabine/tenofovir alafenamide)
Coadministration with Ritlecitinib

Descovy® (FTC/TAF)

Coadministration with Ritlecitinib

This document is in response to your request for information regarding Descovy® (emtricitabine/tenofovir alafenamide [FTC/TAF]) and coadministration with ritlecitinib.

Some data may be outside of the US FDA-approved Prescribing Information. In providing this data, Gilead Sciences, Inc. is not making any representation as to its clinical relevance or to the use of any Gilead product(s). For information about the approved conditions of use of any Gilead drug product, please consult the FDA approved prescribing information.

The full indication, important safety information, and boxed warnings are available at: www.gilead.com/-/media/files/pdfs/medicines/hiv/descovy/descovy_pi.

PK DDI Evaluation

This interaction has not been studied between the fixed-dose combination FTC/TAF and ritlecitinib. Based on the PK profile of each active ingredient within FTC/TAF and ritlecitinib, a PK interaction would not be predicted.1,2  For more information about ritlecitinib, please refer to its product labeling.2

FTC/TAF PK1

Relevant FTC/TAF Label Information1

There is no information in the FTC/TAF product labeling about the coadministration of FTC/TAF and ritlecitinib.

Available Data

There are no Gilead studies evaluating the coadministration of FTC/TAF and ritlecitinib.

Additionally, a literature search was conducted in Ovid MEDLINE and Embase databases for studies published between 1946 and April 10, 2025 using search terms that included Descovy, emtricitabine, tenofovir alafenamide, ritlecitinib, and related search terms. No relevant citations were found.

References

1. Enclosed. Gilead Sciences Inc, DESCOVY® (emtricitabine and tenofovir alafenamide) tablets, for oral use. U.S. Prescribing Information. Foster City, CA.
2. Pfizer Labs, Divison of Pfizer, Inc, LITFULO™ (ritlecitinib) capsules, for oral use. U.S. Prescribing Information. New York, NY.

Abbreviations

BCRP=breast cancer resistance protein
DDI=drug-drug interaction
FTC=emtricitabine
OATP=organic anion transporting polypeptide
P-gp=P-glycoprotein
PK=pharmacokinetic(s)
TAF=tenofovir alafenamide
 

Product Label

For the full indication, important safety information, and boxed warning(s), please refer to the Descovy US Prescribing Information available at:
www.gilead.com/-/media/files/pdfs/medicines/hiv/descovy/descovy_pi.

Follow-Up

For any additional questions, please contact Gilead Medical Information at:

☎1‐866‐MEDI‐GSI (1‐866‐633‐4474) or   www.askgileadmedical.com

Adverse Event Reporting

Please report all adverse events to:

Gilead Global Patient Safety ☎ 1-800-445-3235, option 3 or
 www.gilead.com/utility/contact/report-an-adverse-event

FDA MedWatch Program by ☎ 1-800-FDA-1088 or MedWatch, FDA, 5600 Fishers Ln, Rockville, MD 20852 or   www.accessdata.fda.gov/scripts/medwatch

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